One of the worst things about having the medical diagnosis (as I do)
scientific/medical causes for the myriad symptoms. Because you
do not “look sick” and can’t “prove” how worn out your body seems
or how much pain you’re feeling, many of the people in your life —
including some doctors — start thinking you are “crazy or lazy,” which
can affect your own self-image.
One thing that “makes no sense” to many of my friends and often
to myself, is my felt experience over the past decade that mental and
emotional stressors, and exposure to virtually anyone’s germs, can
be as debilitating as physical exertion or injury for me. It is with some
Study Clarifies Predisposition to Syndrome,” this morning’s Washington
Post (April 21, 2006), which summarizes ”The results, published in more
than a dozen reports and commentaries in the April issue of the journal
The article states, in part (emphasis added):
“An intense battery of medical and psychological tests of people
with chronic fatigue syndrome has strengthened the idea that
the mysterious ailment is actually a collection of five or more
conditions with varying genetic and environmental causes,
scientists reported yesterday.
“But though the syndrome comes in many flavors, these experts
said, the new work also points to an important common feature:
The brains and immune systems of affected people do not respond
normally to physical and psychological stresses.”
” . . . in one analysis, the activity of just 26 genes did accurately
predict which of six categories of chronic fatigue a patient had on
the basis of symptoms and other clinical tests. That is a powerful
hint that those genes — many of them involved in immune system
regulation, the adrenal gland and the brain’s hypothalamus and
pituitary gland, which are involved in the body’s response to stress —
may hold clues to the disease variants.
” . . . It is already known, {CDC’s Suzzane D.] Vernon said, that
the brain can literally rewire itself — breaking old connections between
neurons while building new ones — in response to various physical or
emotional events. Chronic fatigue syndrome may be the result of a
bad rewiring job, she said, in people genetically predisposed to handle
stress poorly.”
“questionDudeS”
“The specific implications remain uncertain for now, said
Vernon, a CDC molecular biologist. “But everybody’s finding
the same five genes to be involved, which is pretty cool.”
“Several other studies on the Wichita samples found abnormal
levels of various hormones relating to stress and mood —
additional evidence that chronic fatigue syndrome patients are
genetically and neurologically “wired” to respond to stress abnormally.”
If you think it’s strange to be thrilled finding out you may indeed have genetic abnor-
malities, you probably have not lived with the uncertainties of an illness like CFS. For
now, I plan to chastise myself less when stressful topics (like here yesterday) seem to
leave me so drained. I will also keep in mind this crucial sentence in the WaPo article:
“The researchers predicted that continued clarification of the precise genes and hormones
involved will lead to better diagnostic tests and therapies for the ailment, which may affect
close to 1 million Americans.”
mom’s arthritis
acting up –
I take two Advil
her beer breath –
tonight,
we both have headaches